Physicians

Physician's Guide to Pharmacogenetic Testing
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We are your primary partner for Molecular Assays. Our high-complexity molecular diagnostic testing services are designed to make it as easy as possible for you to make the best and most accurate decisions for your patients.

What is Pharmacogenetic Testing?

Pharmacogenetics is the study of a patient's genetic ability to metabolize specific medications. Each of us has genetic factors that influence our health and by testing a patient's drug metabolism genes, you can make more informed decisions in finding the best medications and dosages for your patients.

Several genes in the Cytochrome P450 (CYP450) pathway are well characterized in the metabolism of most pharmaceuticals. A patient's variations in these genes can be predictive of their response to a particular drug or dosage. By testing a patient's drug metabolism genes, you can make more informed decisions in finding the best medications and dosages for your patient.

  • Identify genetic differences between people that affect drug response
  • Develop genetic tests that predict an individual's response to a drug
  • Tailor medication treatments to the individual
    • Increase effectiveness
    • Minimize adverse side effects

Physicians

What is the impact on my practice?

We make it easy for you to differentiate your practice with personalized medicine. The patient pays for the cost of testing and they can request reimbursement from their extended health care insurance providers. There are no additional costs to you as the physician and payments are processed online and administered by Medicine Match.

  • Easy online access to order tests and access test results
  • Track patient demographic data for your clinic
  • HIPAA-compliant database
  • EMR integration
  • Research and educational opportunities
  • Exceptional Customer Service and Technical Support

US Organizations adopting Pharmacogenetic Testing

  • Vanderbilt University Medical Centre
  • John Hopkins
  • Mayo Clinic
  • Duke Medical Centre
  • RCIVA Dallas (Cardiovascular & Interventional Vascular Associates)
  • HCA (Hospital Corporation of America)
"When I started doing the molecular testing in the office, certainly we did have some pushback from the other physicians who had trouble understanding how this was going to impact their care, but once they saw a few cases, very illustrative cases, of how this really impacted and changed patients care, they quickly bought into it and then started doing the testing themselves and started seeing the same results, so it was very easy to get other people to understand this."
NICK CAVROS, MD Cardiovascular Institute of the South at Lafayette General, Lafayette, LA

Reduce trial and error at the prescription pad

Instead of the trial-and-error prescription method, physicians are now able to analyze a patient's genetic profile and prescribe the best available personalized drug therapy from the beginning. This takes the guesswork out of finding the right drug, speeds recovery time and increases safety as the likelihood of adverse reactions is eliminated. Pharmacogenomics has the potential to reduce hospitalizations that occur each year in Canada as a result of adverse drug response.

CYP450 Metabolic Activity

Medicine Match provides one-on-one consultation and additional tools for physicians to help interpret genetic test results. The primary genetic variable to consider is the patient's Phenotype.

  • Normal Metabolizer: an individual typically with the wild type of "normal" phenotype - will likely metabolize a drug as anticipated in the package insert.
  • Intermediate Metabolizer: an individual who possesses one partially functional or non-functional allele coding for a metabolizing enzyme - will metabolize a drug, but at a reduced rate.
  • Rapid Metabolizer: an individual with an increased expression of a metabolizing enzyme - will metabolize a drug at a more rapid rate than "normal" and will buildup active metabolites with prodrugs.
  • Poor Metabolizer: an individual with decreased or no expression of a metabolizing enzyme - will metabolize a drug very slowly or not at all and will not produce active metabolite with prodrugs.

Clinical Time Line

Data collection
Validation
Integration into practice

The testing procedure is simple and can be administered by a nurse, physician or pharmacist. A buccal swab sample from the patients' mouth is placed in an envelope and sent to the NMT labs. Lab technicians then extract the patients' DNA and process it through state of the art genetic analysers. Test results, along with interpretative information and dosing suggestions, are securely returned to physicians within 3-5 days.

Benefits of Testing:

  • Detect abnormal drug metabolism phenotypes in your patients.
  • Make dosage or alternative drug decisions for your patient based on patient phenotype.
  • Minimize adverse drug reactions, incorrect dosing effects, or drug inefficacy.
  • Incorporate drug-gene and drug-drug interaction considerations together.
  • Reduce risks and keep the costs of medications down.
  • Allowing patients to be at their best health, sooner.